Mayor Bill de Blasio confirmed that the explosion was caused by a gas leak, at an afternoon briefing.
The leak was reported to ConEdison at 9:13am and crews were dispatched two minutes later but by the time they arrived, the building on the corner of 116th and Park Avenue had already burst into flames.
The 30 injured are being treated at four area hospitals, with at least two of the victims suffering from serious life-threatening injuries. Nine to 12 others are missing, an NYPD source told the New York Daily News.
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Firefighters battle the flames and billowing smoke after a powerful explosion in East Harlem, New York City on Wednesday morning
The devastating scene where two buildings collapsed shortly after a resident in an adjacent building called Con Edison to say she smelled gas
Firefighters work the scene of an explosion as flames leap up the towering heap of rubble
The NYPD help residents at the scene of the massive explosion in Harlem on Wednesday morning
An aerial view of the two collapsed buildings as firefighters search for survivors and battle to get the flames under control
Firefighters extinguish the fire at the site of an alleged powerful explosion in East Harlem, New York. The interior of the building is seen completely destroyed
Rescue workers remove an injured person on a stretcher after an explosion and building collapse in the East Harlem neighborhood of New York
A man covers a child's face as he runs from a building near to the explosion in East Harlem on Wednesday morning
The FDNY respond to a 5-alarm fire and building collapse at 1646 Park Ave in the Harlem neighborhood of Manhattan this morning
Uptown: The blast happened at a building on the corner of 116th and Park Avenue in Manhattan's East Harlem neighbourhood
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